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KMID : 0948320040040020182
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Konyang Medical Journal
2004 Volume.4 No. 2 p.182 ~ p.188
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Severity of Nonalcoholic Fatty Liver Disease and Serum Leptin Level
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Kang Jee-Hyun
Yu Byung-Yeon
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Abstract
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Background: The aim of this study was to elucidate metabolic characteristics by the severity of nonalcoholic fatty liver disease diagnosed by ultrasonography and the relationship between non-alcoholic fatty liver disease to serum leptin level.
Methods: Sixty-nine adult male subjects with negligible alcohol consumption underwent a anthropometric and laboratory investigation including serum leptin level. The ultrasound scan of the liver was performed to determine the presence and the severity of nonalcoholic fatty liver disease.
Results: Nonalcoholic fatty liver disease was diagnosed in 36 cases by ultrasound scan. According to the severity of nonalcoholic fatty liver, serum leptin level, HDL-cholesterol, triglyceride, alanine aminotransferase, aspartate aminotrasnferase, fasting insulin level, HOMA-IR, and obesity related variables (body mass index, percent body fat, waist circumference) showed the significant linear trend. The independent variable accounted for the variance of serum leptin level was serum insulin level and alanine aminotransferase besides obesity related variables.
Conclusion: The severity classification of nonalcoholic fatty liver by ultrasound scan can be used for the prediction of the severity of insulin resistance and the risk of nonalcoholic steatohepatitis. The serum leptin might contribute to the pathophysiology of the nonalcoholic fatty liver disease via insulin resistance and inflammatory response.
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KEYWORD
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nonalcoholic fatty liver disease, serum leptin level, insulin resistance
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